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Microwave‐Induced Stereocontrol of β ‐Lactam Formation with an N ‐Benzylidene‐9,10‐dihydrophenanthren‐3‐amine via Staudinger Cycloaddition
Author(s) -
Bandyopadhyay Debasish,
Banik Bimal K.
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900212
Subject(s) - chemistry , cycloaddition , lactam , stereoselectivity , amine gas treating , microwave irradiation , staudinger reaction , stereochemistry , beta lactam , medicinal chemistry , organic chemistry , catalysis , antibiotics , biochemistry
The synthesis of 3‐substituted 4‐phenyl‐1‐(9,10‐dihydrophenanthren‐3‐yl)azetidin‐2‐ones was achieved following Staudinger cycloaddition under microwave‐induced conditions. The stereoselectivity of β ‐lactam formation depended on the power level of the microwave irradiation used in the experiments.