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Tanacetamide D: A New Ceramide from Tanacetum artemisioides
Author(s) -
Hussain Javid,
Munir Meamoona,
Hassan Zahid,
Bano Naseem,
Arshad Saima,
Ahmad Viqar Uddin
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900204
Subject(s) - heteronuclear molecule , chemistry , two dimensional nuclear magnetic resonance spectroscopy , ceramide , nuclear overhauser effect , stereochemistry , heteronuclear single quantum coherence spectroscopy , nuclear magnetic resonance spectroscopy , amide , organic chemistry , biochemistry , apoptosis
One new ceramide (=long‐chain base linked to a fatty acid via an amide bond), tanacetamide D ( 1 ), was isolated from Tanacetum artemisioides. Besides this, the two known constituents 5‐demethylnobiletin ( 2 ) and 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone ( 3 ) were isolated for the first time from this species. The structure elucidation of the isolated compounds were based primarily on 2D‐NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple‐quantum coherence (HMQC), heteronuclear multiple‐bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.