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Two New 7‐Dehydrobrefeldin A Acids from Cylindrocarpon obtusisporum , an Endophytic Fungus of Trewia nudiflora
Author(s) -
Yu BuZhu,
Zhu Na,
Du ZhiZhi
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900195
Subject(s) - chemistry , stereochemistry , brefeldin a , fungus , strain (injury) , botany , biochemistry , medicine , biology , cell , golgi apparatus
Two new 7‐dehydrobrefeldin A acids, (2 E ,4 R *)‐4‐hydroxy‐4‐{(1 R *,2 S *)‐4‐oxo‐2‐[(1 E )‐6‐oxohept‐1‐en‐1‐yl]cyclopentyl}but‐2‐enoic acid ( 3 ) and (2 E ,4 R *)‐4‐hydroxy‐4‐{(1 R *,2 S *)‐2‐[(1 E ,6 S *)‐6‐hydroxyhept‐1‐en‐1‐yl]‐4‐oxocyclopentyl}but‐2‐enoic acid ( 4 ), were isolated from the endophytic fungal strain Cylindrocarpon obtusisporum ( Cooke & Harkness ) Wollenw . of Trewia nudiflora , together with two known compounds, 7‐dehydrobrefeldin A ( 2 ) and brefeldin A ( 1 ). Their structures were determined on the basis of extensive 1D‐ and 2D‐NMR‐spectral analysis.