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New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.
Author(s) -
Yao Shun,
Ma Li,
Luo JianGuang,
Wang JunSong,
Kong LingYi
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900194
Subject(s) - chemistry , triterpenoid , stereochemistry , hydrolysis , saponin , yeast , traditional medicine , triterpenoid saponin , biochemistry , medicine , alternative medicine , pathology
The seven new triterpenoid saponins 1 – 7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1 D ‐ and 2D‐NMR techniques, HR‐MS, and acid hydrolysis. The isolated compounds include 3,28‐ O ‐bidesmosides with or without a 4‐methoxycinnamoyl group (see 1 vs. 2 and 3 ), and 3‐ O ‐monoglucosides 4 – 7 . All isolated saponins 1 – 7 and their aglycones were evaluated for their α ‐glucosidase inhibition activity. Compound 1 showed inhibitory activity against yeast α ‐glucosidase with an IC 50 value of 100.9±3.3 μ M , whereas compounds 2 – 7 were inactive.
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