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Synthesis of New Tacrine Analogues from 4‐Amino‐1 H ‐pyrrole‐3‐carbonitrile
Author(s) -
Salaheldin Abdellatif M.,
OliveiraCampos Ana M. F.,
Parpot Pier,
Rodrigues Lígia M.,
Oliveira M. Manuel,
Feixoto Francisco P.
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900190
Subject(s) - chemistry , microwave irradiation , pyrrole , tacrine , transformation (genetics) , microwave , irradiation , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , gene , enzyme , biochemistry , physics , quantum mechanics , nuclear physics , acetylcholinesterase
Abstract An easy preparation of 4‐amino‐1 H ‐pyrrole‐3‐carbonitrile derivatives and their transformation into new substituted pyrrolo[3,2‐ b ]pyridines is described. The one‐step transformation was carried out via Friedländer reaction under microwave irradiation and by classical heating methods. The use of microwave irradiation led to high conversion and shorter reaction times.