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Phytoquinoids and Secoprezizaane‐Type Sesquiterpenes from Illicium arborescens
Author(s) -
Chang JiunYang,
Abd ElRazek Mohamed H.,
Chen YuHui,
Cheng YuanBin,
Chen ShunYing,
Chien ChingTe,
Kuo YaoHaur,
Shen YaChing
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900133
Subject(s) - chemistry , sesquiterpene , hela , stereochemistry , phytochemical , epimer , in vitro , cytotoxic t cell , biochemistry
A phytochemical investigation of the MeOH extract of Illicium arborescens yielded the two new phytoquinoid epimers, 2,3‐didehydro‐5‐ O ‐methyl‐11‐epiillifunone E ( 1 ) and 2,3‐didehydro‐5‐ O ‐methylillifunone E ( 2 ), as well as five new sesquiterpene lactones (8,9‐secoprezizaane‐type sesquiterpenes). Two of them, i.e. , 3 and 4 , were minwanensin‐type sesquiterpenes, the other two, i.e. , 5 and 6 , had the anisatin‐type (or floridanolide type) skeleton, and the fifth, i.e. , 7 , was a dunnianin‐type sesquiterpene. Their structures were established by analyses of 1D‐ and 2D‐NMR, HR‐MS, and chemical evidence. The in vitro cytotoxic activity of compounds 1 – 7 was tested against four human tumor cell lines, including HeLa (cervical epitheloid), WiDr (colon), Daoy (medulloblastoma), and Hep2 (liver carcinoma) human‐tumor cells.