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Sesquiterpene Lactones from Daucus glaber
Author(s) -
Sallam Amal A.,
Hitotsuyanagi Yukio,
Mansour ElSayed S.,
Ahmed Atallah F.,
Gedara Sahar,
Fukaya Haruhiko,
Takeya Koichi
Publication year - 2010
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900126
Subject(s) - sesquiterpene , chemistry , sesquiterpene lactone , stereochemistry , lactone
Six new sesquiterpene lactone esters, daucoguaianolactones A–F ( 1 – 6 ), and one new sesquiterpene lactone, daucoeudesmanolactone A ( 7 ) were isolated from the leaves and stems of Daucus glaber ( Forssk .) Thell ., along with the known sesquiterpene lactones talasins A and B and badkhysin. The structures of 1 – 6 were established on the basis of extensive 1D‐ and 2D‐NMR spectroscopic studies and that of 7 by X‐ray crystallography. Compounds 4, 7 , and talasins A and B showed moderate cytotoxicity against P‐388 leukemia cells.