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Six New Triterpenoid Glycosides from Gynostemma pentaphyllum
Author(s) -
Liu JieQing,
Wang CuiFang,
Chen JianChao,
Tu ShangHui,
Gu HongFei,
Hu WenXiang,
Qiu MingHua
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900100
Subject(s) - chemistry , gynostemma pentaphyllum , glycoside , triterpenoid , saponin , stereochemistry , ginseng , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , chromatography , extraction (chemistry) , medicine , alternative medicine , pathology
Six new triterpenoid glycosides, gynosaponins I–VI ( 1 – 6 , resp.), together with three known compounds, ginseng Rb 1 ( 7 ), gypenoside XLIX ( 8 ), and gylongiposide I ( 9 ), were isolated from the aerial parts of Gynostemma pentaphyllum. Based on ESI‐MS, IR, 1D‐ and 2D‐NMR data (HMQC, HMBC, COSY, and TOCSY), the structures of the new compounds were determined as (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)]‐ β ‐glucopyranoside ( 1 ), (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)] [ α ‐rhamnopyranosyl‐(1→3)]‐ β ‐glucopyranoside ( 2 ), (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 3‐ O ‐ β ‐glucopyranosyl‐20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)]‐ β ‐glucopyranoside ( 3 ), (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 3‐ O ‐ β ‐glucopyranosyl‐20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)] [ α ‐rhamnopyranosyl‐(1→3)]‐ β ‐glucopyranoside ( 4 ), (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 3‐ O ‐{[ β ‐glucopyranosyl‐(1→2)]‐ β ‐glucopyranosyl}‐20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)]‐ β ‐glucopyranoside ( 5 ), and (3 β ,12 β ,20 S )‐trihydroxydammar‐24‐ene 3‐ O ‐{[ β ‐glucopyranosyl‐(1→2)]‐ β ‐glucopyranosyl}‐20‐ O ‐[ α ‐rhamnopyranosyl‐(1→2)] [ α ‐rhamnopyranosyl‐(1→3)]‐ β ‐glucopyranoside ( 6 ).