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Multicomponent Approach Towards the Synthesis of Substituted Pyrroles under Supramolecular Catalysis Using β ‐Cyclodextrin as a Catalyst in Water Under Neutral Conditions
Author(s) -
Murthy Sabbavarapu Narayana,
Madhav Bandaru,
Kumar Akkiligunta Vijay,
Rao Kakulapati Rama,
Nageswar Yadavalli Venkata Durga
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900098
Subject(s) - chemistry , supramolecular chemistry , catalysis , cyclodextrin , supramolecular catalysis , combinatorial chemistry , spectroscopy , nuclear magnetic resonance spectroscopy , reaction conditions , organic chemistry , molecule , physics , quantum mechanics
Synthesis of substituted pyrroles in H 2 O by using β ‐cyclodextrin as a supramolecular catalyst is described. This reaction has several advantages over existing methods and provides substituted pyrroles in good‐to‐excellent yields (79–89%). The supramolecular catalysis of the reaction was studied using 1 H‐NMR spectroscopy. β ‐Cyclodextrin can be recovered and reused several times without loss of activity.