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Germacrane‐Type Sesquiterpenes from Curcuma wenyujin
Author(s) -
Lou Yan,
Zhao Feng,
Wu Zhaohua,
Peng KaiFeng,
Wei XingChuan,
Chen LiXia,
Qiu Feng
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900059
Subject(s) - chemistry , sesquiterpene , stereochemistry , nitric oxide , sesquiterpene lactone , terpene , organic chemistry
Two new germacrane‐type sesquiterpene lactones, curdionolides A and B ( 1 and 2 , resp.), and a novel germacrane‐type sesquiterpene lactam, curdionolide C ( 3 ), were isolated from Curcuma wenyujin. Y. H. Chen et C. Ling together with five known germacrane‐type sesquiterpenes, 4 – 8 . The structures of the new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1 – 8 on nitric oxide (NO) production in lipopolysaccharide‐activated macrophages were evaluated.