Premium
Cu‐Mediated Selective N ‐Arylation of Aminotriazole Acyclonucleosides
Author(s) -
Li Wei,
Fan Yuting,
Xia Yi,
Rocchi Palma,
Zhu Ruizhi,
Qu Fanqi,
Neyts Johan,
Iovanna Juan L.,
Peng Ling
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900033
Subject(s) - chemistry , amide , nucleobase , amine gas treating , reagent , nucleic acid , combinatorial chemistry , boronic acid , organic chemistry , dna , biochemistry
Novel N ‐aryltriazole nucleosides were synthesized via a Cu‐mediated CN cross‐coupling reaction, using 3‐aminotriazole acyclonucleosides and various boronic acid reagents. Interestingly, N ‐arylation proceeded much more rapidly on the amide group than on the amine group, leading to selective N ‐arylation of the amide functionality on nucleosides containing both groups on the triazole nucleobase.