Premium
Synthesis of New Conjugates of Modified Podophyllotoxin and Stavudine
Author(s) -
Chen ShiWu,
Xiang Rong,
Tian Xuan
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900012
Subject(s) - chemistry , podophyllotoxin , stavudine , furan , conjugate , stereochemistry , ring (chemistry) , organic chemistry , mathematical analysis , virus , mathematics , virology , viral disease , zidovudine , biology
To find podophyllotoxin compounds with superior bioactivitiy and less toxicity, a series of novel conjugates of ring‐ A ‐modified 4‐epipodophyllotoxin and stavudine with amino acids as spacers were synthesized, i.e. , the N ‐[(2′,3′‐didehydro‐3′‐deoxythymidin‐5′‐ O ‐yl)carbonyl]‐substituted L ‐amino acid rel ‐(3a R ,4 S ,9 R ,9a R )‐1,3,3a,4,9,9a‐hexahydro‐6,7‐dimethoxy‐1‐oxo‐9‐(3,4,5‐trimethoxyphenyl)naphtho[2,3‐ c ]furan‐4‐yl esters 8a – 8f .