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Novel and Highly Effective Method for the Trimethylsilylation of Alcohols and Phenols with Hexamethyldisilazane (HMDS), Catalyzed by I 2 Generated in situ Using Fe(NO 3 ) 3 ⋅9 H 2 O/NaI under Heterogeneous and Neutral Conditions
Author(s) -
Khazaei Ardeshir,
Rahmati Sadegh,
Rostami Amin
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200900002
Subject(s) - chemistry , phenols , yield (engineering) , in situ , catalysis , organic chemistry , metallurgy , materials science
Structurally diverse alcohols and phenols were trimethylsilylated in a clean and efficient reaction with hexamethyldisilazane (HMDS) based on the use of I 2 generated in situ from Fe(NO 3 ) 3 ⋅9 H 2 O/NaI. The reaction occurs very rapid in good‐to‐high yield in CH 2 Cl 2 at room temperature, and the use of toxic and corrosive molecular I 2 is avoided.