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Oligonucleotide Analogues with Integrated Bases and Backbones. Part 19.
Author(s) -
Bogliotti Nicolas,
Ritter Anne,
Hebbe Séverine,
Vasella Andrea
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890236
Subject(s) - chemistry , nucleobase , rheology , oligonucleotide , organic base , base (topology) , polymer chemistry , crystallography , organic chemistry , dna , thermodynamics , biochemistry , mathematical analysis , physics , mathematics
The A*[s]U ( * ) dinucleosides 1 and 2 form thermoreversible gels in organic solvents. The basis of the gelation is the formation of linear aggregates by base pairing following desolvation of the nucleobases. This is evidenced by the absence of gel formation by the C(6) ‐deaminated analogue 3 of 1 , the correlation of gelation with the anti ‐conformation, as preferred for 1 , and the temperature‐, concentration‐, and time‐dependent CD spectra. The gels were also characterized by the minimum gelation concentration, the gel–sol transition (melting) temperature, and rheological properties.