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Eupatozansins A – C, Sesquiterpene Lactones from Eupatorium chinense var. tozanense
Author(s) -
Liaw ChiaChing,
Kuo YaoHaur,
Hwang TsongLong,
Shen YaChing
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890227
Subject(s) - chemistry , eupatorium , phytochemical , sesquiterpene , germacranolide , stereochemistry , terpene , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , biochemistry , medicine
Phytochemical investigation of Eupatorium chinense var. tozanense has resulted in the isolation of three new germacranolides, designated as eupatozansins A–C ( 1 – 3 ), along with five known compounds, (5 S ,6 R ,7 R ,8 R )‐8‐angeloyloxy‐2‐oxoguaia‐1(10),3,11(13)‐trien‐12,6‐olide ( 4 ), costunolide ( 5 ), leptocarpin ( 6 ), 2 α ‐hydroxyeupatolide 8‐ O ‐angelate ( 7 ), and quercetin ( 8 ). The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high‐resolution mass spectrometry. The in vitro cytotoxic activities of compounds 1 – 8 were evaluated.
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