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Synthesis and Characterization of New Binaphthyl‐Linked Phenanthroline‐, Bipyridine‐, or Pyridine‐Derived Ligands, and the Study of Their Cytotoxic Activity
Author(s) -
Beynek Nesrin,
Uluçam Gühergül,
Benkli Kadriye,
Koparal Ays̨e Tansu
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890223
Subject(s) - chemistry , pyridine , cytotoxicity , phenanthroline , stereochemistry , cytotoxic t cell , mtt assay , proton nmr , in vitro , bipyridine , 2,2' bipyridine , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , crystal structure
In the present work, we describe the synthesis and characterization of five new versatile acyclic or macrocyclic ligands containing binaphthyl‐linked pyridine, bipyridine, or phenanthroline groups in their framework (see Schemes 1–4 ). The structures of the ligands were elucidated on the basis of elemental analyses, IR, 1 H‐NMR, 13 C‐NMR, and FAB mass spectra. The cytotoxicity of these compounds was tested in vitro by using the tetrazolium salt reduction (MTT) assay on A549 (human lung carcinoma epithelial like) cells. All of the tested compounds induced time‐ and concentration‐dependent cytotoxic effect.