Premium
New Acyclic 12‐Hydroxygeranylgeraniol‐Derived Diterpenoids from the Seeds of Carpesium triste
Author(s) -
Gao Xue,
Zhang ZhanXin,
Jia ZhongJian
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890206
Subject(s) - chemistry , in vitro , cytotoxic t cell , stereochemistry , biochemistry
Abstract Five new acyclic 12‐hydroxygeranylgeraniol‐derived diterpenoids, i.e. , 1 – 5 , were isolated from the seeds of Carpesium triste. The structures including the absolute configurations of the new compounds were elucidated by spectroscopic methods. All the compounds, except for 2 , were evaluated for their in vitro cytotoxic activity against cultured SMMC‐7721 (human hepatoma), HL‐60 (human promyelocytic leukemia), and L02 (human hepatocyte) cells.