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Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum
Author(s) -
Li DongLi,
Li XiaoMing,
Li TieGang,
Dang HongYue,
Wang BinGui
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890202
Subject(s) - chemistry , dpph , mangrove , hibiscus , fungus , stereochemistry , botany , strain (injury) , organic chemistry , antioxidant , biology , ecology , anatomy
Cultivation of the fungal strain Eurotium rubrum , an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus , resulted in the isolation of two new dioxopiperazine derivatives, namely, dehydrovariecolorin L ( 1 ) and dehydroechinulin ( 2 ), together with eight known dioxopiperazine compounds including variecolorin L ( 3 ), echinulin ( 4 ), isoechinulin A ( 5 ), dihydroxyisoechinulin A ( 6 ), preechinulin ( 7 ), neoechinulin A ( 8 ), neoechinulin E ( 9 ), and cryptoechinuline D ( 10 ). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. Compounds 1, 2, 9 , and 10 were investigated for their α , α ‐diphenyl‐ β ‐picrylhydrazyl (DPPH) radical‐scavenging activity. In addition, the new compounds, 1 and 2 , were evaluated for their cytotoxic activity against the P‐388, HL‐60, and A549 cell lines.