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Chemical Constituents from the Bark of Garcinia xanthochymus and Their 1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) Radical‐Scavenging Activities
Author(s) -
Zhong FangFang,
Chen Yu,
Yang GuangZhong
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890185
Subject(s) - xanthone , chemistry , dpph , garcinia , organic chemistry , phloroglucinol , bark (sound) , clusiaceae , antioxidant , stereochemistry , traditional medicine , medicine , physics , acoustics
A new bis‐xanthone (xanthone=9 H ‐xanthen‐9‐one), named bigarcinenone A ( 1 ) which is the first example of a bis‐xanthone with the xanthone–xanthone linkage between an aromatic C‐atom and a C 5 side chain from a guttiferae plant, a new phloroglucinol (=benzene‐1,3,5‐triol) derivative, named garcinenone F ( 2 ), together with seven known xanthones were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Bigarcinenone A ( 1 ) exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging test with a IC 50 value of 9.2 μ M , compared to the positive control, the well‐known antioxidant butylated hydroxytoluene (BHT) with a IC 50 of 20 μ M ( Table 3 ).