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New Antifungal Terpenoid Glycosides from Alibertia edulis (Rubiaceae)
Author(s) -
Cândida da Silva Viviane,
Soares Mendes Giannini Maria José,
Carbone Virginia,
Piacente Sonia,
Pizza Cosimo,
da Silva Bolzani Vanderlan,
Nasser Lopes Márcia
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890147
Subject(s) - chemistry , terpenoid , saponin , rubiaceae , stereochemistry , glycoside , phytochemical , iridoid , antifungal , candida albicans , traditional medicine , botany , biochemistry , microbiology and biotechnology , biology , medicine , alternative medicine , pathology
Phytochemical investigation from the stems of Alibertia edulis led to the isolation and identification of a new iridoid 6 β ‐hydroxy‐7‐epigardoside methyl ester ( 1 ) and a new saponin 3 β ‐ O ‐[ α ‐ L ‐rhamnopyranosyl‐(1→2)‐ O‐β ‐ D ‐glucopyranosyl‐(1→2)‐ O‐β ‐ D ‐glucopyranosyl]‐28‐ O‐β‐ D ‐glucopyranoside pomolate ( 2 ), along with three known compounds, shanzhiside methyl ester ( 3 ), ixoside ( 4 ), and 3,4,5‐trimethoxyphenyl 1‐ O ‐ β ‐ D ‐apiofuranosyl‐(1→6)‐ O‐β ‐ D ‐glucopyranoside ( 5 ). The structures of 1 and 2 were established on the basis of their spectroscopic data. Iridoid 1 and saponin 2 exhibited moderate inhibitory activities against Candida albicans and C. krusei in a dilution assay.