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Secondary Metabolites from the Stem Bark of Litsea akoensis and Their Cytotoxic Activity
Author(s) -
Chang SuYen,
Cheng MingJen,
Kuo YuehHsiung,
Lee ShiowJu,
Chang HsunShuo,
Chen IhSheng
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890125
Subject(s) - chemistry , moiety , cytotoxic t cell , in vitro , stereochemistry , human breast , cell culture , cancer cell lines , cytotoxicity , cancer cell , biochemistry , cancer , medicine , biology , genetics
Six new butanolides, litseadioxanins A and B ( 1 and 2 , resp.) bearing a 1,2‐dioxane moiety, litseatrinolides A and B ( 3 and 4 , resp.), and litseakolides D 1 and D 2 ( 5 and 6 , resp.), were isolated from the stem bark of Litsea akoensis , together with six known compounds. The structures of the new compounds were characterized by in‐depth NMR‐spectroscopic and mass‐spectrometric analyses. Butanolides 1 – 4 , and a mixture of 6 and litsenolide E 2 , and litsenolide B 1 were tested against human tumor cells, including MCF‐7 (human breast adenocarcinoma), NCI‐H460 (non‐small‐cell lung cancer), and SF‐268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B 1 exhibited marginal cytotoxic activity against MCF‐7, NCI‐H460, and SF‐268 cell lines in vitro.