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ent ‐Kaurane Diterpenoids from Isodon phyllostachys
Author(s) -
Li Xian,
Weng ZhiYing,
Li Yong,
Pu JianXin,
Huang ShengXiong,
Xiao WeiLie,
Sun HanDong
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890121
Subject(s) - chemistry , phytochemical , stereochemistry , phyllostachys , terpene , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , botany , bamboo , biochemistry , medicine , biology
Phytochemical investigation of the medicinal plant Isodon phyllostachys led to the isolation of four new ent ‐kaurane diterpenoids, phyllostacins F–I ( 1 – 4 , resp.), together with 11 known compounds, rosthorin A ( 5 ), rabdoternin C ( 6 ), enmenol ( 7 ), oridonin ( 8 ), lasiocarpanin ( 9 ), xerophilusin B ( 10 ), ponicidin ( 11 ), macrocalin B ( 12 ), phyllostachysin A ( 13 ), sculponeatin C ( 14 ), and macrocalyxoformin E ( 15 ). The structures of the new compounds were established by spectroscopic methods, including extensive 1D‐ and 2D‐NMR analyses. Compounds 1, 2, 7, 10 , and 13 were evaluated for their inhibitory activity against K562 and HepG2 cell lines.