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Eremophilane‐Type Sesquiterpenes from the Roots of Ligularia virgaurea
Author(s) -
Zhang ZhanXin,
Fei DongQing,
Jia ZhongJian
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890112
Subject(s) - chemistry , stereochemistry , sesquiterpene , spectral analysis , spectroscopy , physics , quantum mechanics
From the roots of Ligularia virgaurea , five new eremophilane‐type sesquiterpenes were isolated, including three new eremophilenolides, 6 β ‐(angeloyloxy)‐1 α ,8 β ,10 β ‐trihydroxyeremophil‐7(11)‐en‐12,8 α ‐olide ( 1 ), 6 β ‐(angeloyloxy)‐1 β ,10 β ‐epoxy‐8 β ‐ethoxyeremophil‐7(11)‐en‐12,8 α ‐olide ( 2 ), and 1 β ,10 β ‐epoxy‐8 β ‐ethoxy‐6 β ‐[(2‐methylacryloyl)oxy]eremophil‐7(11)‐en‐12,8 α ‐olide ( 3 ), two new noreremophilanes, 3 β ‐[(2‐methylacryloyl)oxy]‐8‐oxo‐12‐noreremophil‐6‐en‐11‐one ( 9 ), and 9 β ‐hydroxy‐8‐oxo‐12‐noreremophil‐6‐en‐11‐one ( 10 ), and six known eremophilanes, namely 4 – 8 , and 11 . Their structures were elucidated by means of spectral methods, such as IR, HR‐ESI‐MS, and 1D‐ and 2D‐NMR, and by comparison of the spectral data with those reported for structurally related compounds.