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Secondary Metabolites from the Leaves of Litsea lii var. nunkao‐tahangensis
Author(s) -
Wang TzuAnn,
Cheng MingJen,
Lee ShiowJu,
Yang ChengWei,
Chang HsunShuo,
Chen IhSheng
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890111
Subject(s) - chemistry , cytotoxic t cell , in vitro , stereochemistry , cell culture , biochemistry , genetics , biology
Investigation of the leaves extract of Litsea lii var. nunkao‐tahangensis led to the isolation of five new butanolides, litsealiicolide A ( 1 ), isolitsealiicolide A ( 2 ), litsealiicolide B ( 3 ), isolitsealiicolide B ( 4 ), and isolitsealiicolide C ( 5 ), along with 17 known compounds. Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolates, compounds 1 and 2 were cytotoxic against MCF‐7, NCI‐H460, and SF‐268 cell lines in vitro. Compound 5 and isolinderanolide B ( 6 ) showed marginal cytotoxic activity against these three cell lines in vitro.