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A Mild and Efficient Method for N ‐Arylnucleobase Synthesis via the Cross‐Coupling Reactions of Nucleobases with Arylboronic Acids Catalyzed by Simple Copper Salts
Author(s) -
Tao Lan,
Yue Yang,
Zhang Ji,
Chen ShanYong,
Yu XiaoQi
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890107
Subject(s) - nucleobase , chemistry , catalysis , copper , aryl , salt (chemistry) , coupling (piping) , combinatorial chemistry , solvent , coupling reaction , organic chemistry , dna , biochemistry , mechanical engineering , alkyl , engineering
A simple and efficient copper‐salt catalyzed N ‐arylation of nucleobases is reported. In a mixed solvent of MeOH and H 2 O, the coupling products were obtained in moderate to excellent yields at room temperature within a short time. A variety of substituted N ‐aryl nucleobases can be prepared through this procedure.