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Baimantuoluolines D – F, Three New Withanolides from the Flower of Datura metel L.
Author(s) -
Yang Bingyou,
Wang Qiuhong,
Xia Yonggang,
Feng Weisheng,
Kuang Haixue
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890103
Subject(s) - withanolide , chemistry , stereochemistry , lignan , medicine , alternative medicine , pathology , withania somnifera
Three new withanolide compounds, named baimantuoluolines D–F, along with three known withanolides and a lignan were isolated from the flower of Datura metel L., the parts effective against psoriasis. The structures of the new compounds were elucidated as (5 α ,6 β ,12 β ,20 R ,22 R ,24 R ,25 S )‐21,24‐epoxy‐5,6,12‐trihydroxy‐27‐methoxy‐1‐oxowith‐2‐enolide ( 1 ), (5 α ,6 β ,12 β ,20 R ,22 R ,24 R ,25 S )‐21,24‐epoxy‐5,6,12,27‐tetrahydroxy‐1‐oxowith‐2‐enolide ( 2 ), and (5 α ,6 β ,12 β ,22 R )‐5,6,12,21‐tetrahydroxy‐1‐oxowith‐24‐enolide( 3 ) on the basis of physicochemical evidence.