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A New Diterpenoid and a New Diterpenoid Alkaloid from Aconitum coreanum
Author(s) -
Yang ChunHua,
Wang XiaChang,
Tang QingFa,
Liu WenYing,
Liu JingHan
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890078
Subject(s) - guan , terpenoid , aconitum , chemistry , stereochemistry , alkaloid , diterpene , traditional medicine , humanities , philosophy , medicine
Abstract A new diterpenoid, guan fu diterpenoid A ( 1 ), and a new diterpenoid alkaloid, guan fu base S ( 2 ), were isolated from the Chinese medicinal herb Aconitum coreanum ( Lèvl. ) Rapaics , together with five known diterpenoid alkaloids guan fu base P, guan fu base R, guan fu base G, guan fu base F, and guan fu base Z. The structures of the two new compounds were elucidated as ent ‐kaurane‐16,20‐diol ( 1 ) and (11 β ,13 S )‐2,3,15,16‐tetradehydro‐16,17‐dihydrohetisan‐11,13,14‐triol 11,13‐diacetate ( 2 ) on the basis of HR‐MS and 2D‐NMR analyses. This is the first report of an ent ‐kaurane diterpenoid in Aconitum coreanum.