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Modified Cyclodextrins as Enantioselective Hosts for Amino Acids
Author(s) -
Kumar Vydyula Pavan,
Suryanarayana Iragavarapu,
Nageswar Yadavalli Venkata Durga,
Rao Kakulapati Rama
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890077
Subject(s) - chemistry , moiety , enantiomer , enantioselective synthesis , amino acid , fluorescence , stereochemistry , organic chemistry , biochemistry , catalysis , physics , quantum mechanics
Two modified β ‐cyclodextrins, H‐2 and H‐3 , having a flexible appended moiety were studied for the chiral discrimination of the enantiomers of various amino acids by means of fluorescence as signaling option. These hosts quenched the fluorescence intensities of amino acids upon binding. The d‐ enantiomers were better recognized by these hosts. The association constants ( K s ) and enantioselectivity factors ( α ) of the host⋅guest complexes were calculated.