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Improved Synthesis of Phytosphingosine and Dihydrosphingosine from 3,4,6‐Tri‐ O ‐benzyl‐ D ‐galactal
Author(s) -
Niu Youhong,
Cao Xiaoping,
Ye XinShan
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890076
Subject(s) - chemistry , yield (engineering) , mitsunobu reaction , combinatorial chemistry , stereochemistry , metallurgy , materials science
An efficient and facile synthesis of phytosphingosine and dihydrosphingosine derivatives is described with less steps and in improved overall yield (66–72%) starting from commercially available tri‐ O ‐benzyl‐ D ‐galactal. The key steps include Wittig reaction, Mitsunobu transformation, reduction, and deprotection.