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New Oxygenated Lignans from Kadsura philippinensis
Author(s) -
Shen YaChing,
Lin YuChi,
Cheng YuanBin,
Chang ChiaJu,
Lan TingWei,
Liou ShorongShii,
Chien ChingTe,
Liaw ChiaChing,
Khalil Ashraf Taha
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890052
Subject(s) - chemistry , two dimensional nuclear magnetic resonance spectroscopy , moiety , stereochemistry , lignan , biphenyl , ring (chemistry) , nuclear magnetic resonance spectroscopy , fractionation , organic chemistry
Seven new oxygenated lignans, kadsuphilins G–M ( 1 – 7 , resp.), were isolated by chromatographic fractionation of an AcOEt extract of the aerial part of Kadsura philippinensis including four compounds with a dibenzocyclooctadiene skeleton, two with a bicyclooctane ring system, and one of 1,4‐biphenyldimethylbutane type. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D‐NMR experiments (HMQC, HMBC, and NOESY). The configuration of the chiral centers and the biphenyl moiety were determined by NOESY as well as CD spectroscopy, respectively.