Enantioselective Synthesis of  β ‐Blockers  via  Hydrolytic Kinetic Resolution of Terminal Oxiranes by Using Bimetallic Chiral {{2,2′‐[Cyclohexane‐1,2‐diylbis(nitrilomethylidyne)]bis[phenolato]}(2−)}cobalt ([Co(salen)])‐Type Complexes | Zendy

Kawthekar Rahul B. | Zendy; Kim GeonJoong | Zendy

Premium

Enantioselective Synthesis of β ‐Blockers via Hydrolytic Kinetic Resolution of Terminal Oxiranes by Using Bimetallic Chiral {{2,2′‐[Cyclohexane‐1,2‐diylbis(nitrilomethylidyne)]bis[phenolato]}(2−)}cobalt ([Co(salen)])‐Type Complexes

Author(s) -

Kawthekar Rahul B.,

Kim GeonJoong

Publication year - 2008

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200890037

Subject(s) - chemistry , bimetallic strip , kinetic resolution , enantioselective synthesis , hydrolysis , cobalt , cyclohexane , medicinal chemistry , catalysis , polymer chemistry , organic chemistry

The synthesis of chirally pure β ‐blockers was successfully achieved via hydrolytic kinetic resolution of butyl (±)‐4‐(oxiran‐2‐ylmethoxy)benzeneacetate ((±)‐ 1 ) and (±)‐4‐(oxiran‐2‐ylmethoxy)benzeneacetonitrile ((±)‐ 2 ) in the presence of bimetallic chiral [Co(salen)]‐type complexes. The newly synthesized bimetallic chiral [Co(salen)]‐type complexes exhibited excellent enantioselectivities of up to >98% ee in good yields ( Tables 1 – 3 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research