Copper‐Free  Sonogashira  Coupling of Acid Chlorides with Terminal Alkynes in the Presence of a Reusable Palladium Catalyst: An Improved Synthesis of 3‐Iodochromenones (=3‐Iodo‐4 H ‐1‐benzopyran‐4‐ones) | Zendy

Likhar Pravin R. | Zendy; Subhas M. S. | Zendy; Roy Moumita | Zendy; Roy Sarabindu | Zendy; Kantam M. Lakshmi | Zendy

Premium

Copper‐Free Sonogashira Coupling of Acid Chlorides with Terminal Alkynes in the Presence of a Reusable Palladium Catalyst: An Improved Synthesis of 3‐Iodochromenones (=3‐Iodo‐4 H ‐1‐benzopyran‐4‐ones)

Author(s) -

Likhar Pravin R.,

Subhas M. S.,

Roy Moumita,

Roy Sarabindu,

Kantam M. Lakshmi

Publication year - 2008

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200890032

Subject(s) - chemistry , sonogashira coupling , catalysis , palladium , cerium , yield (engineering) , ammonium nitrate , copper , palladium catalyst , medicinal chemistry , alkyne , organic chemistry , materials science , metallurgy

Pd/C is used as an efficient catalyst for the copper‐free Sonogashira coupling of acid chlorides and terminal alkynes to afford ynones in high yields ( Tables 1 and 3 ). Cyclization of (2‐methoxyaryl)‐substituted ynones induced by I 2 /ammonium cerium(IV) nitrate (CAN) at room temperature gave 3‐iodochromenones (=3‐iodo‐4 H ‐1‐benzopyran‐4‐ones) in excellent yield ( Table 4 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research