Premium
Synthesis of 4‐(Isothiazol‐3‐yl)morpholines and 1‐(Isothiazol‐3‐yl)piperazines, and Their Inhibitory Activity towards Acetylcholinesterase
Author(s) -
Wolf Janine,
Tanarro Camino M. González,
Gütschow Michael,
Sieler Joachim,
Schulze Bärbel
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890010
Subject(s) - chemistry , electrophorus , acetylcholinesterase , stereochemistry , organic chemistry , enzyme , biochemistry , acetylcholine receptor , receptor , torpedo
The synthesis of novel triaryl‐substituted 4‐(isothiazol‐3‐yl)morpholines 7 and 8 , and 1‐(isothiazol‐3‐yl)piperazines 9 – 13 by reaction of the corresponding isothiazolium salts 5 and 6 with secondary amines in the presence of t ‐BuOK in absolute THF is described. Some representatives of the isothiazoles were evaluated as inhibitors of acetylcholinesterase from Electrophorus electricus.