Synthesis of 4‐(Isothiazol‐3‐yl)morpholines and 1‐(Isothiazol‐3‐yl)piperazines, and Their Inhibitory Activity towards Acetylcholinesterase | Zendy

Wolf Janine | Zendy; Tanarro Camino M. González | Zendy; Gütschow Michael | Zendy; Sieler Joachim | Zendy; Schulze Bärbel | Zendy

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Synthesis of 4‐(Isothiazol‐3‐yl)morpholines and 1‐(Isothiazol‐3‐yl)piperazines, and Their Inhibitory Activity towards Acetylcholinesterase

Author(s) -

Wolf Janine,

Tanarro Camino M. González,

Gütschow Michael,

Sieler Joachim,

Schulze Bärbel

Publication year - 2008

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200890010

Subject(s) - chemistry , electrophorus , acetylcholinesterase , stereochemistry , organic chemistry , enzyme , biochemistry , acetylcholine receptor , receptor , torpedo

The synthesis of novel triaryl‐substituted 4‐(isothiazol‐3‐yl)morpholines 7 and 8 , and 1‐(isothiazol‐3‐yl)piperazines 9 – 13 by reaction of the corresponding isothiazolium salts 5 and 6 with secondary amines in the presence of t ‐BuOK in absolute THF is described. Some representatives of the isothiazoles were evaluated as inhibitors of acetylcholinesterase from Electrophorus electricus.

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