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Secondary Metabolites from the Fungus Chaetomium brasiliense
Author(s) -
Li GuoYou,
Li BoGang,
Yang Tao,
Liu GuangYe,
Zhang GuoLin
Publication year - 2008
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200890002
Subject(s) - chemistry , fungus , chromone , human breast , ethyl acetate , stereochemistry , fermentation , hydroxymethyl , cell culture , human lung , cancer cell lines , biochemistry , cancer cell , botany , cancer , medicine , genetics , biology
Two new depsidones, mollicellins I and J ( 1 and 2 , resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin ( 3 ), along with six known compounds, 4 – 9 , were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated based on spectroscopic analysis. Mollicellins I and H ( 5 ) exhibited significant growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines with GI 50 values between 2.5–8.6 μg/ml.