Bioactive Cytochalasins from  Aspergillus flavipes , an Endophytic Fungus Associated with the Mangrove Plant  Acanthus ilicifolius | Zendy

Lin ZhenJian | Zendy; Zhang GuoJian | Zendy; Zhu TianJiao | Zendy; Liu Rui | Zendy; Wei HongJuan | Zendy; Gu QianQun | Zendy

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Bioactive Cytochalasins from Aspergillus flavipes , an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius

Author(s) -

Lin ZhenJian,

Zhang GuoJian,

Zhu TianJiao,

Liu Rui,

Wei HongJuan,

Gu QianQun

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200800455

Subject(s) - mangrove , chemistry , cytochalasin , fungus , botany , plant use of endophytic fungi in defense , aspergillus , biology , biochemistry , cell , ecology , cytoskeleton

Five new cytochalasins, Z 16 –Z 20 ( 1 – 5 ), and three known ones, 6 – 8 , were isolated from Aspergillus flavipes , an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z 17 ( 2 ) and rosellichalasin ( 8 ) showed cytotoxic activities against A‐549 cell lines with IC 50 values of 5.6 and 7.9 μ M , respectively.

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