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Bioactive Cytochalasins from Aspergillus flavipes , an Endophytic Fungus Associated with the Mangrove Plant Acanthus ilicifolius
Author(s) -
Lin ZhenJian,
Zhang GuoJian,
Zhu TianJiao,
Liu Rui,
Wei HongJuan,
Gu QianQun
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800455
Subject(s) - mangrove , chemistry , cytochalasin , fungus , botany , plant use of endophytic fungi in defense , aspergillus , biology , biochemistry , cell , ecology , cytoskeleton
Five new cytochalasins, Z 16 –Z 20 ( 1 – 5 ), and three known ones, 6 – 8 , were isolated from Aspergillus flavipes , an endophytic fungus associated with Acanthus ilicifolius. Their structures were elucidated on the basis of comprehensive spectral analysis. Cytochalasin Z 17 ( 2 ) and rosellichalasin ( 8 ) showed cytotoxic activities against A‐549 cell lines with IC 50 values of 5.6 and 7.9 μ M , respectively.