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Three New ent‐ Labdane Diterpenoids from the Wood of Excoecaria agallocha Linn .
Author(s) -
Gowri Ponnapalli Mangala,
Bhattar Sri Vedavyasa Srirangaraja Radhakrishnan,
Reddy Poreddy Guruva,
Rakesh Yerraballi,
Basha Shaik Jeelani,
Sarma Akella Venkata Subrahmanya,
Rao Janaswamy Madhusudana
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800448
Subject(s) - labdane , chemistry , stereochemistry , traditional medicine , diterpene , medicine
An extensive study of metabolites present in Excoecaria agallocha Linn . led to the isolation of three new ent ‐labdane‐type diterpenoids, named agallochaexcoerins A–C ( 1 – 3 ), besides three known compounds. The skeleton present in compound 1 is rather unusual, containing of a seven‐membered lactone. The structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. The isolated compounds 1 – 6 were not active against Raw 264.7 (macrophage‐like), K 562 (leukemia), and COLO 205 (colon) human carcinoma cell lines.