Three New  ent‐ Labdane Diterpenoids from the Wood of  Excoecaria agallocha   Linn . | Zendy

Gowri Ponnapalli Mangala | Zendy; Bhattar Sri Vedavyasa Srirangaraja Radhakrishnan | Zendy; Reddy Poreddy Guruva | Zendy; Rakesh Yerraballi | Zendy; Basha Shaik Jeelani | Zendy; Sarma Akella Venkata Subrahmanya | Zendy; Rao Janaswamy Madhusudana | Zendy

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Three New ent‐ Labdane Diterpenoids from the Wood of Excoecaria agallocha Linn .

Author(s) -

Gowri Ponnapalli Mangala,

Bhattar Sri Vedavyasa Srirangaraja Radhakrishnan,

Reddy Poreddy Guruva,

Rakesh Yerraballi,

Basha Shaik Jeelani,

Sarma Akella Venkata Subrahmanya,

Rao Janaswamy Madhusudana

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200800448

Subject(s) - labdane , chemistry , stereochemistry , traditional medicine , diterpene , medicine

An extensive study of metabolites present in Excoecaria agallocha Linn . led to the isolation of three new ent ‐labdane‐type diterpenoids, named agallochaexcoerins A–C ( 1 – 3 ), besides three known compounds. The skeleton present in compound 1 is rather unusual, containing of a seven‐membered lactone. The structures were elucidated on the basis of spectroscopic studies and comparison with known related compounds. The isolated compounds 1 – 6 were not active against Raw 264.7 (macrophage‐like), K 562 (leukemia), and COLO 205 (colon) human carcinoma cell lines.

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