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Diterpenoids from the Hainan Soft Coral Sinularia parva
Author(s) -
Li Yan,
Gao AnHui,
Huang Hui,
Li Jia,
Mollo Ernesto,
Gavagnin Margherita,
Cimino Guido,
Gu YuCheng,
Guo YueWei
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800447
Subject(s) - chemistry , moiety , coral , stereochemistry , in vitro , cytotoxic t cell , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , ecology , biology
Two new cembrane diterpenes, sinulaparvalides A and B ( 1 and 2 , resp.), which contain an intriguing seven‐membered lactone moiety, along with the four known related cembranoids 3 – 6 , were isolated from the Hainan soft coral Sinularia parva. The structures of compounds 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D‐NMR techniques, and were confirmed by single‐crystal X‐ray diffraction analysis. The in vitro cytotoxic activities of these compounds were tested on human colon carcinoma (HCT‐116), human promyelocytic leukemia (HL‐60), and human lung carcinoma (A‐549) tumor cell lines.