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Labdane and Tetranorlabdane Diterpenoids from Botryosphaeria sp. MHF, an Endophytic fungus of Maytenus hookeri
Author(s) -
Yuan Lin,
Zhao PeiJi,
Ma Juan,
Lu ChunHua,
Shen YueMao
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800424
Subject(s) - chemistry , labdane , candida albicans , antifungal , plant use of endophytic fungi in defense , stereochemistry , botany , terpenoid , microbiology and biotechnology , biology
Five new diterpenoids, named botryosphaerins A–E ( 1 – 5 , resp.), including one labdane and four tetranorlabdane diterpenes, were isolated from the solid culture of the endophytic fungal strain Botryosphaeria sp. MHF of Maytenus hookeri , together with seven known diterpenoids, namely 13,14,15,16‐tetranorlabd‐7‐ene‐19,6 β : 12,17‐diolide ( 6 ), acrostalidic acid ( 7 ), acrostalic acid ( 8 ), agathic acid ( 9 ), isocupressic acid ( 10 ), LL‐Z1271 β ( 11 ), and CJ‐14445 ( 12 ). The structures of all compounds were established on the basis of comprehensive spectroscopic studies. The relative configurations of 1 and 2 were determined by single‐crystal X‐ray diffraction analyses. All compounds except 4 were evaluated for their inhibitory activities against several pathogenic bacterial and fungal strains. However, only compound 12 showed significant inhibitions against Candida albicans, Saccharomyces cerevisiae , and Penicillium avellaneum UC‐4376 with nystatin as a positive control.