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Highly Efficient Synthesis of Thieno[2,3‐ b ]indole Derivatives
Author(s) -
Boeini Hassan Zali
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800423
Subject(s) - chemistry , indole test , combinatorial chemistry , reaction conditions , stereochemistry , medicinal chemistry , organic chemistry , catalysis
Thieno[2,3‐ b ]indole derivatives were efficiently prepared via the reaction of 1,3‐dihydro‐2 H ‐indole‐2‐thiones with α ‐bromo‐substituted ketones or aldehydes and in the presence of Et 3 N ( Scheme 2 and Table ). The reaction took place under very mild conditions and in short times with good to excellent yields.