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Simple and Efficient Friedel–Crafts Alkylation of 1 H ‐Indole with Electron‐Deficient Alkenes Promoted by Zinc Acetate
Author(s) -
Meshram Harshadas Mitaram,
Kumar Dachepally Aravind,
Reddy Bandi Chennakesava
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800410
Subject(s) - chemistry , alkylation , friedel–crafts reaction , indole test , zinc , organic chemistry , nitro , catalysis , alkyl
An efficient method for the Friedel–Crafts alkylation of 1 H ‐indole with nitro alkenes in the presence of zinc acetate is described. The procedure is applicable to a variety of nitro alkenes and substituted indoles, and the yields are very high.