Premium
Chemical Constituents from Clerodendrum bungei and Their Cytotoxic Activities
Author(s) -
Liu ShanShan,
Zhou Tong,
Zhang ShuWei,
Xuan LiJiang
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800392
Subject(s) - chemistry , hela , phenylethanoid , glycoside , stereochemistry , in vitro , cytotoxic t cell , biochemistry
A new phenylethanoid glycoside, two new cyclohexylethanoids, one new phenolic glycoside, and a new farnesane‐type sesquiterpenoid, namely 2‐phenylethyl 3‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ β ‐ D ‐glucopyranoside ( 1 ), 6″‐ O ‐[( E )‐caffeoyl] rengyoside B ( 2 ), clerodenone A ( 3 ), 2‐({6‐ O ‐[(4‐hydroxy‐3‐methoxyphenyl)carbonyl]‐ β ‐ D ‐glucopyranosyl}oxy)‐2‐methylbutanoic acid ( 4 ), 2‐{(2 S ,5 R )‐5‐[(1 E )‐4‐hydroxy‐4‐methylhexa‐1,5‐dien‐1‐yl]‐5‐methyltetrahydrofuran‐2‐yl}propan‐2‐yl β ‐ D ‐glucopyranoside ( 5 ), together with 16 known compounds, were isolated from the roots of Clerodendrum bungei. All structures were elucidated by spectroscopic methods. The new compounds showed modest in vitro inhibition of the proliferation of the HeLa human cervical carcinoma cell line (CCL‐2), with IC 50 values in the range of 3.5–8.7 μ M , adriamycin being used as positive control, with an IC 50 value of 0.026±0.001 μ M .