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Scalarane Sesterterpenes from the Chinese Sponge Phyllospongia foliascens
Author(s) -
Zhang HongJun,
Tang HaiFeng,
Yi YangHua,
Lin HouWen
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800377
Subject(s) - chemistry , sponge , stereochemistry , cytotoxic t cell , acetone , botany , organic chemistry , biochemistry , biology , in vitro
Three new scalarane sesterterpenes, phyllofolactone L ( 1 ), phyllofenone D ( 2 ) and phyllofenone E ( 3 ), were isolated from the acetone extract of the South China Sea sponge Phyllospongia foliascens. Their structures were elucidated on the basis of spectroscopic analysis. Phyllofenone D ( 2 ) was cytotoxic against the P388 leukemia cell line with an IC 50 value of 6.5 μg/ml.