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Convenient Access to β ‐Substituted Chiral Phenones
Author(s) -
Cao XiuFang,
Hu Ming,
Li Fei,
Lu WenChang,
Yu GuangAo,
Liu ShengHua
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800375
Subject(s) - synthon , chemistry , enantioselective synthesis , reagent , combinatorial chemistry , catalysis , table (database) , organic chemistry , stereochemistry , database , computer science
A highly enantioselective approach towards the synthesis of β ‐substituted chiral ketones by utilizing Grignard reagents was achieved. The ( R )‐ and ( S )‐antipodes of the target chiral ketones 2a – 2k were obtained with up to 100% ee from chiral N ‐alkanoylcamphorsultams 1 ( Scheme, Table 2 ). This simple, catalyst‐free, direct procedure for the formation of chiral ketones is a fascinating method for the practical syntheses of chiral synthons as valuable building blocks and important medicinal intermediates.