Synthesis of Substituted 1,8‐Naphthyridine‐3‐carboxylates from  Baylis–Hillman  Adducts of Substituted 2‐Chloronicotinaldehydes | Zendy

Narender Puli | Zendy; Ravinder Mettu | Zendy; Sadhu Partha Sarathi | Zendy; China Raju Bhimapaka | Zendy; Ramesh Chilukuri | Zendy; Jayathirtha Rao Vaidya | Zendy

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Synthesis of Substituted 1,8‐Naphthyridine‐3‐carboxylates from Baylis–Hillman Adducts of Substituted 2‐Chloronicotinaldehydes

Author(s) -

Narender Puli,

Ravinder Mettu,

Sadhu Partha Sarathi,

China Raju Bhimapaka,

Ramesh Chilukuri,

Jayathirtha Rao Vaidya

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200800352

Subject(s) - chemistry , adduct , azide , baylis–hillman reaction , reduction (mathematics) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , geometry , mathematics

A series of substituted 1,8‐naphthyridine‐3‐carboxylates were synthesized for the first time from the Baylis–Hillman adducts obtained from 2‐chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8‐naphthyridine‐3‐carboxylates, of which the azide‐reduction route ( Scheme 5 ) gave the best yields compared to the other attempted methods ( Schemes 2 and 3 ).

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