Premium
Cathepsin B Inhibitory Tetraene Lactones from the Fungus Talaromyces wortmannii
Author(s) -
Dong Yuesheng,
Lin Jie,
Lu Xinhua,
Zheng Zhihui,
Ren Xiao,
Zhang Hua,
He Jiangong,
Yang Junshan
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800333
Subject(s) - chemistry , moiety , fungus , stereochemistry , cathepsin b , inhibitory postsynaptic potential , heptane , biochemistry , enzyme , organic chemistry , botany , neuroscience , biology
Wortmannilactones E–H ( 1 – 4 ), four new cathepsin B inhibitors, were produced and isolated from the culture of the soil filamentous fungus Talaromyces wortmannii. Their structures and relative configurations were elucidated on the basis of 1D‐ and 2D‐NMR techniques, three of them ( 1, 2 , and 4 ) posses an oxabicyclo[2.2.1]heptane moiety. Compounds 1 – 4 showed inhibitory activities against cathepsin B with IC 50 values of 4.3, 6.5, 13.0, and 6.0 μ M , respectively.