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Efficient One‐Pot 1,3‐Dibromo‐5,5‐dimethylhydantoin (DBH)‐Catalyzed Synthesis of Highly Substituted Furans
Author(s) -
GhasemnejadBosra Hassan,
Faraje Mohammad,
Habibzadeh Setareh
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800310
Subject(s) - chemistry , catalysis , furan , solvent , organic chemistry , medicinal chemistry , combinatorial chemistry
The 1,3‐dibromo‐5,5‐dimethylhydantoin (DBH) was found to efficiently catalyze the one‐pot synthesis of highly functionalized tetrasubstituted furan derivatives by the reaction of 1,4‐diarylbut‐2‐ene‐1,4‐diones and acetoacetates in i‐PrOH as the solvent at 80–90° for 3–7 h. The products were formed in high yields (82–95%) under mild and neutral conditions.