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Two New Cytotoxic Biphenyls from the Roots of Incarvillea arguta
Author(s) -
Fu JianJun,
Jin HuiZi,
Shen YunHeng,
Qin JiangJiang,
Wang Yan,
Huang Ying,
Zeng Qi,
Yan ShiKai,
Zhang WeiDong
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800305
Subject(s) - chemistry , cytotoxicity , stereochemistry , cytotoxic t cell , methylcyclopentane , mtt assay , two dimensional nuclear magnetic resonance spectroscopy , medicinal chemistry , in vitro , organic chemistry , biochemistry , selectivity , catalysis
Two novel biphenyls, named incargutines A ( 1 ) and B ( 2 ), were isolated from the roots of Incarvillea arguta , and the structures were elucidated by detailed spectroscopic analysis, including HR‐ESI‐MS data and 2D‐NMR spectroscopy. Compounds 1 and 2 contain an unprecedented C‐atom skeleton, namely a 4‐methylbiphenyl unit fused with a 7‐methylcyclopentane unit at C(2) and C(3) ( i.e. , a 1,7‐dimethyl‐4‐phenylindane skeleton). The cytotoxicity of 1 and 2 was evaluated with four tumor cell lines, A549, LOVO, CEM, and MDA‐MB‐435 (MDA), by an MTT assay.