One‐Pot Synthesis of 5‐Substituted 1 H ‐Tetrazoles from Aryl Bromides with Potassium Hexakis(cyano‐ κC )ferrate(4−) (K 4 [Fe(CN) 6 ]) as Cyanide Source | Zendy

Zhu Yizhong | Zendy; Ren Yiming | Zendy; Cai Chun | Zendy

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One‐Pot Synthesis of 5‐Substituted 1 H ‐Tetrazoles from Aryl Bromides with Potassium Hexakis(cyano‐ κC )ferrate(4−) (K 4 [Fe(CN) 6 ]) as Cyanide Source

Author(s) -

Zhu Yizhong,

Ren Yiming,

Cai Chun

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200800254

Subject(s) - chemistry , dabco , bromide , aryl , cyanide , potassium cyanide , medicinal chemistry , potassium , octane , potassium ferrate , organic chemistry , alkyl

A one‐pot procedure for the synthesis of 5‐substituted 1 H ‐tetrazoles through the three‐component reaction between an aryl bromide, potassium hexakis(cyano‐ κC )ferrate(4−) (K 4 [Fe(CN) 6 ]) and NaN 3 catalyzed by [Pd(OAc) 2 ] and ZnBr 2 in the presence of 1,4‐diazabicyclo[2.2.2]octane (dabco) was developed. Furthermore, the reaction occurred under nonacidic conditions and involved a nontoxic cyanide source, making this method a quite attractive one.

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