New Eremophilanolides from  Ligularia hodgsonii | Zendy

Xu YangJun | Zendy; Nan ZeDong | Zendy; Li WenHai | Zendy; Huang HongLi | Zendy; Yuan ChengShan | Zendy

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New Eremophilanolides from Ligularia hodgsonii

Author(s) -

Xu YangJun,

Nan ZeDong,

Li WenHai,

Huang HongLi,

Yuan ChengShan

Publication year - 2009

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.200800250

Subject(s) - chemistry , rhizome , stereochemistry , phytochemical , antibacterial activity , traditional medicine , bacteria , biochemistry , medicine , biology , genetics

A phytochemical study on the roots and rhizomes of Ligularia hodgsonii led to the isolation of seven new eremophilanolides ( 1 – 7 ), their structures were established as (1 R ,4 S ,5 S ,6 R ,8 S ,10 R )‐1‐acetoxyeremophil‐7(11)‐en‐6,15;8,12‐diolide ( 1 ), (1 R ,4 S ,5 S ,6 R ,8 S ,10 R )‐1‐acetoxy‐8 β ‐hydroxyeremophil‐7(11)‐en‐6,15;8,12‐diolide ( 2 ), (4 S ,5 S ,6 R ,8 R ,9 S ,10 S )‐8‐hydroxy‐9‐(angeloyloxy)eremophil‐7(11)‐en‐6,15;8,12‐diolide ( 3 ), (4 S ,5 S ,6 R ,10 R )‐10‐hydroxyeremophil‐7(11),8(9)‐diene‐6,15;8,12‐diolide ( 4 ), (4 S ,5 S ,6 R ,8 R , 10 R )‐6‐(angeloyloxy)‐8‐hydroxyeremophil‐7(11)‐en‐8,12‐olide‐15‐carboxylic acid methyl ester ( 5 ), (4 S ,5 S ,6 R ,8 R ,10 R )‐6‐(angeloyloxy)‐8‐ethoxyeremophil‐7(11)‐en‐8,12‐olid‐15‐oic acid ( 6 ), (4 S ,5 S ,6 S , 8 R ,10 R )‐6‐(angeloyloxy)‐8 ‐ ethoxyeremophil‐7(11)‐en‐8,12‐olid‐15‐oic acid ( 7 ) by means of spectroscopic analyses. The compounds were also evaluated for antibacterial activity, only compound 6 exhibited antibacterial activity against Bacillus subtilis.

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