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New Eremophilanolides from Ligularia hodgsonii
Author(s) -
Xu YangJun,
Nan ZeDong,
Li WenHai,
Huang HongLi,
Yuan ChengShan
Publication year - 2009
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200800250
Subject(s) - chemistry , rhizome , stereochemistry , phytochemical , antibacterial activity , traditional medicine , bacteria , biochemistry , medicine , biology , genetics
AbstractA phytochemical study on the roots and rhizomes of Ligularia hodgsonii led to the isolation of seven new eremophilanolides ( 1 – 7 ), their structures were established as (1 R ,4 S ,5 S ,6 R ,8 S ,10 R )‐1‐acetoxyeremophil‐7(11)‐en‐6,15;8,12‐diolide ( 1 ), (1 R ,4 S ,5 S ,6 R ,8 S ,10 R )‐1‐acetoxy‐8 β ‐hydroxyeremophil‐7(11)‐en‐6,15;8,12‐diolide ( 2 ), (4 S ,5 S ,6 R ,8 R ,9 S ,10 S )‐8‐hydroxy‐9‐(angeloyloxy)eremophil‐7(11)‐en‐6,15;8,12‐diolide ( 3 ), (4 S ,5 S ,6 R ,10 R )‐10‐hydroxyeremophil‐7(11),8(9)‐diene‐6,15;8,12‐diolide ( 4 ), (4 S ,5 S ,6 R ,8 R , 10 R )‐6‐(angeloyloxy)‐8‐hydroxyeremophil‐7(11)‐en‐8,12‐olide‐15‐carboxylic acid methyl ester ( 5 ), (4 S ,5 S ,6 R ,8 R ,10 R )‐6‐(angeloyloxy)‐8‐ethoxyeremophil‐7(11)‐en‐8,12‐olid‐15‐oic acid ( 6 ), (4 S ,5 S ,6 S , 8 R ,10 R )‐6‐(angeloyloxy)‐8 ‐ ethoxyeremophil‐7(11)‐en‐8,12‐olid‐15‐oic acid ( 7 ) by means of spectroscopic analyses. The compounds were also evaluated for antibacterial activity, only compound 6 exhibited antibacterial activity against Bacillus subtilis.