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A Novel ‘Domino‐Click Approach’ to Unsymmetrical Bis‐1 H ‐1,2,3‐triazoles
Author(s) -
Banday Abid H.,
Arora Bhupinder S.,
Alam Mohammed S.,
Kumar Halmuthur M. Sampath
Publication year - 2007
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.200790242
Subject(s) - chemistry , domino , cycloaddition , aryl , click chemistry , combinatorial chemistry , bromide , medicinal chemistry , organic chemistry , catalysis , alkyl
Aryl azides 1 were treated with allenylmagnesium bromide ( 2 ) to generate 1,5‐disubstituted butynyl‐1 H ‐1,2,3‐triazoles 3 in a domino fashion, which upon Cu I ‐catalyzed 1,3‐dipolar cycloaddition with aryl azides 4 afforded novel bis‐1 H ‐1,2,3‐triazoles 5 in quantitative yields ( Scheme 1 and Table ).